Endocrine Abstracts

Introduction: DDP4i improves the function of β-cells and α-cells. However, there have been short-term follow-up and young subjects in many experimental and clinical studies. The imbalance of pancreatic endocrinocytes increases in adulthood and changes become less reversible. We decided that it would be useful to study the morphofunctional features of pancreatic endocrinocytes while taking iDPP4 in the older age group in the clinic and experimentally.<p class="abs...

Introduction: New medicinal products that have been introduced into first-line therapy for type 2 diabetes mellitus (T2DM) include glucagon-like peptide-1 receptor agonists (GLP-1ra) and dipeptidyl peptidase-4 inhibitors (DPP-4i). These products have been shown to increase beta-cell proliferation. Some studies also demonstrated an increase in pancreatic alpha-cell proliferation. Various sulfonylureas drugs (SU) have been shown to produce different effects on apoptosis pancreat...